Armenian Journal of Physics

The isotherm of hybridization for the DNA field-effect transistor in presence of monovalent charged ligands

Hakobyan, A. (2017) The isotherm of hybridization for the DNA field-effect transistor in presence of monovalent charged ligands. Armenian Journal of Physics, 10 (4). pp. 206-211. ISSN 1829-1171

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Abstract

Motivated by the prospects of developing DNA field-effect transistors, as tools for a variety of application fields, such as medical diagnostics, environmental pollutants monitoring, biological weapons defense, and taking into account that the efficiency of DNA – sensors depends on the precise prediction of experimental parameters responsible for thermostability of nucleic acids duplexes and specific times of formation of DNA duplexes, we analyze the factors influencing both the thermodynamics of hybridization and the stability of DNA-DNA and DNA-RNA duplexes. We analyze the case of competition-free DNA hybridization, showing how the intercalating charged and charge-free ligands effectively increase the binding constant for the target sequences and thus affects the sensitivity of the DNA chip. The monovalent charged ligands increase sensitivity of DNA sensors in comparison with charge-free ligands.

Item Type:Article
Subjects:Physics > 30.Atomic and molecular physics
Physics > 81.Materials science
ID Code:920
Deposited By:Prof. Vladimir Aroutiounian
Deposited On:27 Dec 2017 20:13
Last Modified:27 Dec 2017 20:13

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